毛囊:一种新型的多功能干细胞来源组织工程和再生医学

发布时间:2017-06-13 点击数:524

一、source textHair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine

二、译  :毛囊:一种新型的多功能干细胞来源组织工程和再生医学

三、Abstract

the hair follicle(HF)is dynamic mini organ supporting important biological functions of the body. HFs protect against cold potential injuries; they also have an important sensory and immunologic functions in addition to influencing social behavior, HFs are easily accessible and contain stem cells from diverse developmental origins that continuously self-renew, differentiate, regulate hair growth, and contribute to skin homeostasis. Hair follicle stem cells(HF-SCs) have been shown to be highly proliferative in vitro and multipotent, thereby enabling engineering of various tissues for organ replacement and regenerative medicine. In addition, genetic engineering of the HF stem cells in vivo has shown promising results, suggesting that treatment of genetic diseases of skin or hair via HF-SC engineering may be feasible. The present review summarizes the existing literature regarding the differentiation potential of HF-SCs, their putative markers, common isolation methods, and potential applications in cell and gene therapies.

四、摘要译文

毛囊是动态的微型器官支持身体的重要的生物功能。毛囊抵御寒冷的潜在伤害,他们也有一个重要的感官和免疫功能影响社会行为,毛囊容易取得而且含有原始干细胞,可以不断自我更新,分化,调节头发生长,有助于皮肤内稳态。毛囊干细胞(HF-SCs)已被证明具有体外高度增殖和多种功能的细胞,从而使工程的各种组织器官替代和再生医学。此外,毛囊干细胞的基因工程在活体内取得不错的效果,提倡治疗皮肤的遗传疾病或头发通过毛囊干细胞工程是可行的。现在回顾总结了现有文献关于毛囊干细胞的分化潜能,所属假定的标记,以及在细胞和基因疗法中常见的分离方法和潜在的应用。

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