生长因子和细胞因子对毛囊发育和营养循环:最近从动物模型和临床治疗潜力的观察

发布时间:2017-06-13 点击数:592

一、source textGrowth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy

二、译 :生长因子和细胞因子对毛囊发育和营养循环:最近从动物模型和临床治疗潜力的观察

三、Abstract

Hair growth disorders, particularly those that lead to hair loss (alopecia), are common and frequently cause significant mental anguish in affecter; individuals, the mechanisms underlying the majority of these disorders are unknown. However, insights into the specific molecular mechanisms of hair follicle development and cycling have recently been made using animal models, particularly mice that over-or under express a specific gene for a growth factor or cytokine. Other animal models have demonstrated that certain growth factors and cytokines can prevent much of the alopecia caused by cancer chemotherapeutic agents. These animal models have confirmed the importance of growth factors and cytokines in hair follicle development and cycling, and have formed the foundation for potential clinical therapy of hair growth disorders, particularly alopecia. Nevertheless, important questions concerning their efficacy, safety and delivery will need to be answered before successful clinical therapy of any hair growth disorder becomes a reality.

四、摘要译文:

头发生长障碍,特别是脱发(秃头症)是最常见的,经常造成精神上的重大痛苦;个体中大多数疾病的机制是未知的。然而,深入观察毛囊的具体分子发展机制和营养循环动物模型,尤其是老鼠在表达特定生长因子和细胞因子的基因。其他动物模型表明,某些生长因子和细胞因子可以防止癌症化疗药物引起的脱发。这些动物模型也证实了毛囊生长因子和细胞因子对毛囊发育和营养循环的重要性,并形成了潜在的头发生长障碍临床治疗的基础,特别是脱发。然而,重要的问题关于他们的疗效、安全性和交付成功的临床治疗前需要回答任何毛发生长障碍成为现实。

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